CLnZyme DNase I
CLnZyme DNase I is the recombinant DNase I which is a deoxyribonuclease that cleaves DNA preferentially at phosphodiester linkages adjacent
to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing
tetranucleotides. It acts on single-stranded DNA, double-stranded DNA, and chromatin. In addition to its role as a waste-management
endonuclease, it has been suggested to be one of the deoxyribonucleases responsible for DNA fragmentation during apoptosis. DNase I
nonspecifically catalyzes the degradation of both single- and double-stranded DNA, and DNA-RNA hybrids, producing 5'-phosphate and
3'-hydroxyl termini-containing oligonucleotides of varying lengths.